Polynucleotides: New generation regenerative injection

Cosmetic medicine in Marseille

Injectable polynucleotides are one of the most effective treatments in aesthetic medicine for improving skin quality.
They stimulate collagen and elastin production and treat difficult areas such as the eye contour. At Phenicia Clinic, our protocol uses recognized salmon DNA-based products such as Nucleofill or PhilArt.
They are sometimes referred to as "salmon sperm injections," but they are actually purified polynucleotide chains.

Make an appointment
Definition of polynucleotides

Polynucleotides: what are they really?

Polynucleotide injections at the PHENICIA Clinic in Marseille

Polynucleotides are highly purified DNA fragments capable of activating a set of biological processes already exploited in gene therapy. Their mechanism of action is based on three major levers:

Deep hydration and cell repair

When injected into the dermis, polynucleotides act like a water magnet. This deep hydration immediately improves skin texture, radiance, and elasticity.

Intense stimulation of collagen and elastin

By reactivating fibroblasts, we achieve a genuine anti-aging effect that is structural , long-lasting, and preventive, far superior to a simple conventional skin booster.

Antioxidant and anti-inflammatory action

Enhanced cellular protection that contributes to improved skin tolerance, even on areas known to be difficult.
They belong to the same biomolecular family as polypeptides, but with greater regenerative power.

Indications

A key treatment for the face and dark circles

Polynucleotide technology is relevant for:

Treatment of dark circles

This is one of the signature indications. The product can be injected into the skin around the eyes to:

  • Fill in light to moderate dark circles with a biological, non-volumizing effect.
  • Improve dark circles under the eyes,
  • Reduce dark circles under the eyes,
  • Treat certain types of dark circles that are resistant to hyaluronic acid.

Facial treatment

Firming, refined pores, wrinkled skin, fine lines, slight sagging.

Prevention of aging

Ideal approach from age 30 onwards to slow down the deterioration of support fibers.

Skin improvement

Improves skin texture, radiance, and sensitivity.

Is there an alternative?

Polynucleotides vs. hyaluronic acid: two distinct approaches

Unlike hyaluronic acid, which is used to fill and hydrate, polynucleotides act as a regenerative booster. They do not add volume: they improve the skin deeply, in a restorative and functionalway . Around the eyes, this treatment reduces the risk of overcorrection or puffiness associated with hyaluronic acid.

Procedure

How does an injection session work?

Prior medical consultation

Assessment of the dermis, analysis of the type of dark circles, exclusion of autoimmune diseases, and personalized treatment plan.

The injection session

  • drooping upper eyelid,
  • Microinjections in layers or at cannula entry points
  • The procedure takes 10 to 20 minutes.
  • Immediate resumption of activities

The products can be used as monotherapy or as part of an advanced protocol combining lasers, peels, or biostimulators.

Results

A natural, gradual, and controlled effect

A renewed radiance from the very first week

Deep, long-lasting hydration

Gradual smoothing of fine lines

A marked improvement in the eye contour area

Improved skin density thanks to revitalized collagen

Combination with other techniques in aesthetic medicine

Contraindications

What are the contraindications for polynucleotide injections?

Polynucleotide injections for dark circles in Marseille at the Phenicia Clinic

Injections are not recommended in the following cases:

  • Pregnancy/breastfeeding,
  • Active skin infections,
  • Uncontrolled autoimmune diseases,
  • Known hypersensitivity to the components,
  • History of severe inflammation in the treated area.

Polynucleotides: how much do these injections cost?

At Clinique Phénicia and Phénicia Medical Spa, polynucleotide injections are offered as a complete treatment program.

€900 for a course of 3 sessions
Make an appointment
Polynucleotides in Marseille

Why choose Phenicia Clinic for your polynucleotide injections?

A regenerative approach to the eye contour area

Polynucleotides are used at the Phenicia Clinic for tissue repair and skin quality, particularly around the eyes.

The clinic takes a long-term view: healthier, more stable skin that is more resistant to aging.

The commitments of the Phenicia Clinic

  • Specialized expertise in the eye contour area
    Protocols adapted to the delicate anatomy of the eye area to treat dark circles, fine lines, and wrinkles.
  • Careful selection of products used
    Reference polynucleotides, chosen for their safety and clinical results.
  • Premium, secure clinical environment
    Technical facilities dedicated to cosmetic medicine and surgery.
  • Protocols mastered by healthcare professionals
    Physicians trained in advanced aesthetic medicine.
  • Biomedical focus on regeneration
    Tissue engineering, biostimulation, and functional approach to the skin.